Thursday, 13th February 37th Lorne Cancer Conference 2025

• Environmental and Age-Related Drivers of Lung Cancer: Insights into Inflammation and Tumor Progression - Charles Swanton
• Metabolic triggers for cancer genome evolution - Ashok Venkitaraman
• Epithelial Reprogramming into a Fetal-Like Regenerative State - Dustin Flanagan
• Origins and signals of early lung tumourigenesis - Clare Weeden
• Tumour sequencing to aid germline variant classification and reveal mutational events driving tumorigenesis - Nic Waddell

Session Sponsored by:

• Targeting Fusion-driven Cancers - Kimberly Stegmaier
• Perioperative clinical trial reveals decreased synaptic signaling and restoration of metabolism as mechanisms of mutant IDH inhibition - Jim Whittle
• Innovations in brain immunology and immunotherapy in brain tumors - David M Ashley
• BRAF-fusion partners induce novel therapeutic vulnerabilities - Pratiti Bandopadhayay

Flash Talks

Ibukun Adejumobi
Identification of Multipotent Progenitor Cells in Oesophageal Submucosal Glands through Single-Cell Transcriptomics and Organoid Cultures: Implications for Barrett’s Metaplasia

Diego Chacon-Fajardo
Enhancing Tumour Response in Pancreatic Cancer: The Role of Itraconazole

Sreeja Gadipally
Cellular adaptation in breast cancer metastasis and treatment resistance

Somi Kordafshari
Single cell mapping of transcriptomic diversity and spatial dynamics in rare breast cancer subtypes

Laura Marruecos
Deciphering the cell-of-origin in BRCA1-derived ovarian cancer

Michael Milevskiy
Characterising the gene regulation and development of breast progenitor cells

Kendelle Murphy
Pulsed priming with narmafotinib reduces fibrosis and enhances both gemcitabine/Abraxane & FOLFIRINOX response in pancreatic cancer

Session Sponsored by:

Odd numbered posters must be attended in the first hour (7:30PM - 8:30PM)

Even numbered posters must be attended in the second hour (8:30PM - 9:30PM)

• Deciphering chemotherapy resistance mechanisms in mucinous ovarian cancer via barcode clonal tracking - Suad Abdirahman
• Identification of Multipotent Progenitor Cells in Oesophageal Submucosal Glands through Single-Cell Transcriptomics and Organoid Cultures: Implications for Barrett’s Metaplasia - Ibukun IA Adejumobi
• Using novel engineered mouse models to tackle molecular heterogeneity in KRAS-driven lung cancer - Lauren Ashwood
• LIN28B as a potential diagnostic and prognostic marker and a pharmacological target for paediatric medulloblastoma - Iman Azimi
• The Cellular Landscape of In-Transit Melanoma and Resistance to Immune Checkpoint Blockade - Louise Baldwin
• Establishment characterisation and utilisation of nine novel patient derived osteosarcoma cell lines - Zara A Barger
• Drug screening in organoid models identifies novel combination therapies for the treatment of ovarian carcinosarcoma   - Holly Barker
• Spatial resolution of the head and neck cancer tumour microenvironment to identify tumour and stromal features associated with therapy response - Naomi Berrell
• A novel mouse model to study the role of mdm2 and its transcriptional regulation in p53-mediated tumour suppression - Reet Bhandari
• Optimisation of cell free tumour DNA extraction from peritoneal lavage fluid for biomarker analysis - Brodie Bilston
• TX5, a novel transport protein that facilitates melanoma progression - Claudine Bonder
• The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer. - Kara Britt
• CBL mutations unlock new therapeutic opportunities in paediatric CNS and solid tumours - Lauren M Brown
• Investigating the role of γδ T cells in metastatic breast cancer - Rebecca Brown
• Modulating mRNA translation to prevent cancer cell state switching - Christina HT Bui
• Exploring the therapeutic potential of ACHM-025, a novel AKR1C3-activated prodrug, in preclinical models of paediatric T-cell acute lymphoblastic leukaemia - Ruilin Cai
• Investigating the metabolic regulation of alternative polyadenylation in cancer - Nicola E Caine
• The multi-omic landscape of somatic variation across a pan-cancer cohort of brain metastases - Bethany Campbell
• Enhancing Tumour Response in Pancreatic Cancer: The Role of Itraconazole - Diego Chacon-Fajardo
• Utilising gene-editing technology to uncover novel immunotherapies for targeting bone metastases in breast cancer - Thomas B Chadwick
• Single-cell TCR α/β and TCR γ/δ immune receptor profiling and immunophenotyping using a sorted cell approach for target discovery and validation  - Alex Chenchik
• Exploring and targeting chemotherapy-induced cellular senescence in medulloblastoma brain cancer - Charmaine Chng
• Exploiting RNA processing to overcome therapy resistance in melanoma - Helayna Christofi
• Mechanisms of oncogenic JNK signalling in metastatic triple-negative breast cancer - Misaki S Clearwater
• Small-molecule inhibition of human telomerase - Scott Cohen
• Multi-omic immune profiling of paediatric solid tumours - Erin Coll
• Establishing a precision medicine pipeline for paediatric acute myeloid leukaemia. - Patrick Connerty
• Dynamic regulation of integrin β1 phosphorylation supports invasive breast cancer progression - James RW Conway
• Single-cell ligand-receptor analysis reveals dormant myeloma cell control pathways in the skeleton - Alexander Corr
• Tumour Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism - Thomas R Cox
• Alterations in the epigenetic machinery associated with prostate cancer health disparities - Jenna Craddock
• Comparative analysis of different single-cell CRISPR-Seq protocols using the 10X Genomics platform - Paul Diehl
• The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment - Meg L Donovan
• CT45 as a biomarker in prognosis of Ovarian Cancer - Harshita Dubey
• Gene regulation in the developing retina and the childhood eye cancer retinoblastoma - David D Eisenstat
• Tackling immune escape: identifying novel targets and pathways involved in the regulation of CD155 - Fenna F Feenstra
• New murine model of glioblastoma recapitulates human phenotypes - Devlin R Forsythe
• Establishment of a novel quiescence-tracking mouse model of high-grade glioma - Dana Friess
• Characterization of the immune microenvironment in pancreatic cancer following SARS-CoV-2 infection - Ka Yee Fung
• Characterising the role of kat5 in zebrafish development and disease. - Gurveer Kaur GK Gaddu
• Cellular adaptation in breast cancer metastasis and treatment resistance - Sreeja R Gadipally
• Investigating the Role of Calcitonin Receptor Knockout in Cancer Cell Growth, Autophagy and Apoptosis - Tahereh Gharbi
• Identifying and targeting FOLFIRINOX resistance mechanisms to improve outcomes in pancreatic cancer - Katie Gordon
• Developing new therapies in mucinous ovarian cancer - Irina Gorobets
• MIOFlo reveals temporal transcriptional relationships across the cancer cell-state landscape - Shabarni Gupta
• Characterising epithelial-to-mesenchymal transition in ovarian carcinosarcoma preclinical models to identify new targets for treatment - Anthony Hadla
• A Comprehensive R Workflow for Normalization, Differential Metabolomics Analysis, and Metabolite Set Enrichment Analysis (MSEA) in Melanoma Models - Fayrouz FH Hammal
• Accumulation and activity of FOXO1-CAR T cells enhanced by carboplatin-induced microenvironment modulations within human prostate cancer model - Sophie G Harrison
• Targeting the interplay between replication stress (RS) induced DNA damage response (DDR) and epigenetics in children with high-risk neuroblastoma and sarcoma - Hannah E. Hartley
• Sensitisation and eradication of chemo-resistant pediatric ETP-ALL by repurposing decitabine - Jackie Huang
• Lineage-restricted differentiation therapy of acute myeloid leukaemia - Samin Iranfar
• Modelling T cell and cancer cell interactions to examine immune checkpoint inhibition resistance in pancreatic ductal adenocarcinoma - Aji Istadi
• Advancing Precision Diagnostics With Multiomics And 3D Tumour Modelling - Binny Jaradi
• EXPLORING NOVEL PHAGE THERAPY BY TARGETING FUSOBACTERIUM NUCLEATUM IN GASTRIC CANCER - Birhanu Jemere
• Identify rare and common cell types through single-cell ensemble clustering - Xinnan Jin
• Deciphering mechanisms underpinning tobacco-unassociated lung tumourigenesis to improve patient outcomes - Rachel Joyce
• Identification of the Mechanisms Underlying Poor Response to Standard of Care Therapy in Childhood and Adolescent Osteosarcoma through Whole Genome CRISPR cut Screens. - Barnaby Kelly
• Molecular determinants of sensitivity and resistance to a novel AKR1C3 activated prodrug in paediatric leukaemia - Faezeh Khalili
• Exploring cellular heterogeneity of localised breast cancers –Exploring cellular heterogeneity of localised breast cancers –from bench to breakthroughs - Beata Kiedik
• Playing by Different Rules: Heterogeneity in Epithelial and Mesenchymal Cancer Cell States Pre-determines Differences in Acute EGF Signalling - Felix V Kohane
• Single cell mapping of transcriptomic diversity and spatial dynamics in rare breast cancer subtypes   - Somi Kordafshari
• Unravelling the tumour landscape of pancreatic cancer - Clara C Kosasih
• Understanding the genetic determinants regulating AKR1C3 expression in acute lymphoblastic leukaemia - Hansen J Kosasih
• Oncoprotein moonlighting: Non-canonical tumour suppression in melanoma by the metabolic enzyme IMPDH2 - Gamze Kuser Abali
• Genomic and Transcriptomic landscape of long-term survivors of pancreatic ductal adenocarcinoma - Hue Mai La
• Effect of endocytosis inhibition on the safety and efficacy of trastuzumab and trastuzumab-deruxtecan therapy to treat HER2⁺ breast cancer using humanised patient-derived xenograft murine models - Jason J Lee
• Utilising evolution to optimise live bacterial therapeutics for colorectal cancer treatment - Julia Leeflang
• Establishment of patient-derived models of metastatic appendiceal cancers - King Ho Leong
• Targeting prostate cancer via surface presentation of PSA peptides - Eleanor W Leung
• Streamlining IVT RNA Production and LNP Encapsulation for Advanced Gene Therapy - Thomas Leung
• Diacylglycerol kinase inhibition improves treatment response in KRAS mutant lung cancer - Elizabeth Lieschke
• High-throughput design of hypermethylation markers for Barrett’s oesophagus with dysplasia and oesophageal adenocarcinoma - Yi Jin Liew
• Doubling down on targeted therapy-resistance: Co-inhibiting CDK4/6 and PRMT5 proves effective - Lydia Lim
• Investigating the role of structural variants and methylation in lung cancer through long-read sequencing - Lingchen Liu
• hoodscanR: profiling single-cell neighborhoods in spatial transcriptomics data - Ning Liu
• Transcriptional regulation of acute myeloid leukaemia stem cells by the IL-3 receptor - Nora W. Liu
• Targeting the lipid metabolism of alveolar type II cells decreases lung metastasis - Xiao-Zheng Liu
• Ikaros and the white whale; or the detection of terminal exon deletions from RNA-seq in a paediatric B-cell ALL cohort - Andrew Lonsdale
• Targeting epigenetic deregulation in pancreatic cancer via Protein Arginine Methyltransferase 5 (PRMT5) inhibition as a promising therapeutic strategy - Johana Luhur
• Repurposing FDA-approved drugs to target therapy induced invadopodia-mediated invasion in glioblastoma - Zhahna Maharani
• The impact of a developing immune system on immunotherapy efficacy in paediatric cancer - Sebastien SM Malinge
• Peritoneal tumour DNA as a prognostic biomarker in locally advanced gastroesophageal cancer: A pilot prospective cohort study - Sasha Witts